Follow-up na IVF/ICSI

In dit project wordt de neuromotore en cognitieve ontwikkeling gedurende de eerste twee jaren van kinderen die geboren zijn na verschillende vormen van hulp bij voortplanting, zoals IVF en ICSI in kaart gebracht.
Inmiddels leerde het onderzoek ons dat de neurologische ontwikkeling van kinderen geboren na IVF/ICSI tot en met de leeftijd van 2 jaar niet verschilt van die van kinderen geboren uit ouders die ondanks vruchtbaarheidsproblemen toch spontaan zwanger werden. Wel zagen we dat kinderen van ouders met vruchtbaarheidsproblemen (dus onafhankelijk van het feit of er gebruik gemaakt was van IVF of ICSI) op 3 maanden niet iets minder optimaal functioneerden dan de kinderen van ouders zonder vruchtbaarheidsproblemen.

Onderzoekers:

Prof. Dr. Arie Bos -  Beatrix Kinderkliniek, UMCG
Dr. Maaike Haadsma - Medische Genetica
Prof. Dr. Mijna Hadders-Algra - Ontwikkelingsneurologie
Prof. Dr. Maas-Jan Heineman - Disciplinegr. Obstet & Gynacol, UMCG
Drs. Karin Middelburg - Ontwikkelingsneurologie
Pamela Schendelaar - Ontwikkelingsneurologie
Jorien Seggers - Ontwikkelingsneurologie

Financiële ondersteuning:

Doelmatigheidsgelden UMCG, Cornelia Stichting, BCN

Recente publicaties:

  1. Middelburg KJ, Heineman MJ, Bos AF, Hadders-Algra M. Neuromotor, cognitive, language and behavioural outcome in children born following IVF or ICSI  a systematic review. Hum Reprod Update 2008; 14: 219-31.
  2. Middelburg KJ, Heineman MJ, Bos AF, Pereboom M, Fidler V, Hadders-Algra M. The Groningen ART cohort study: ovarian hyperstimulation and the in vitro procedure do not affect neurological outcome in infancy. Hum Reprod 2009; 24: 3119-26.
  3. Middelburg KJ, Haadsma ML, Heineman MJ, Bos AF, Hadders-Algra M. Ovarian hyperstimulation and the in-vitro procedure do not influence early neuromotor development, a history of subfertility does.  Fertil Steril 2009, e-pub ahead of print.
  4. Middelburg KJ, Heineman MJ, Haadsma ML, Bos AF, Kok JH, Hadders-Algra M. Neurological condition of infants born following preimplantation genetic screening. Pediatr Res 2010, 2010;93:544-53.
  5. Pelinck MJ, Hadders-Algra M, Haadsma ML, Nijhuis WJ, Kiewiet SM, Hoek A, Heineman MJ, Middelburg KJ. Is the birthweight of singletons born after IVF reduced by ovarian stimulation or by IVF laboratory procedures?. Reprod Biomed Online 2010; 21: 245-51.
  6.  Middelburg KJ, Heineman MJ, Haadsma ML, Bos AF, Kok JH, Hadders-Algra M. Neurological condition of infants born following preimplantation genetic screening. Pediatr Res 2010, e-pub ahead of print..
  7. Schendelaar P, Middelburg KJ, Bos AF, Heineman MJ, Jongbloed-Pereboom M, Hadders-Algra M. The Groningen ART-cohort study: the effects of ovarian hyperstimulation and the IVF laboratory procedures on neurological condition at 2 years. Hum Reprod, in press.

Follow-up after IVF/ICSI

This project aims at evaluating neuromotor and cognitive development till the age of two years in children born after various forms of assisted reproduction.
Until now the data revealed that neurological development until the age of 2 years of children born after IVF or ICSI did not differ from that of children born to couples with fertility problems who conceived naturally. In addition we found that children of subfertile couples (whether or not conceived with help of IVF or ICSI) showed a less optimal neurological condition at 3 months than children of fertile couples.

Main investigators:

Arie Bos, MD, PhD - Beatrix Childrens Hospital, UMCG
Maaike Haadsma, MD, PhD - Medical Genetics, UMCG
Mijna Hadders-Algra, MD, PhD - Developmental Neurology
Maas-Jan Heineman, MD, PhD - Dept. Obstet & Gynacol, uMCGDrs.
Karin Middelburg, MD - Developmental Neurology
Pamela Schendelaar - Developmental Neurology
Jorien Seggers - Developmental Neurology

Financial support:

Doelmatigheidsgelden UMCG, Cornelia Stichting, BCN

Recent pulications:

  1. Middelburg KJ, Heineman MJ, Bos AF, Hadders-Algra M. Neuromotor, cognitive, language and behavioural outcome in children born following IVF or ICSI  a systematic review. Hum Reprod Update 2008; 14: 219-31.
  2. Middelburg KJ, Heineman MJ, Bos AF, Pereboom M, Fidler V, Hadders-Algra M. The Groningen ART cohort study: ovarian hyperstimulation and the in vitro procedure do not affect neurological outcome in infancy. Hum Reprod 2009; 24: 3119-26.
  3. Middelburg KJ, Haadsma ML, Heineman MJ, Bos AF, Hadders-Algra M. Ovarian hyperstimulation and the in-vitro procedure do not influence early neuromotor development, a history of subfertility does.  Fertil Steril 2009, e-pub ahead of print.
  4. Middelburg KJ, Heineman MJ, Haadsma ML, Bos AF, Kok JH, Hadders-Algra M. Neurological condition of infants born following preimplantation genetic screening. Pediatr Res 2010, 2010;93:544-53.
  5. Pelinck MJ, Hadders-Algra M, Haadsma ML, Nijhuis WJ, Kiewiet SM, Hoek A, Heineman MJ, Middelburg KJ. Is the birthweight of singletons born after IVF reduced by ovarian stimulation or by IVF laboratory procedures?. Reprod Biomed Online 2010; 21: 245-51.
  6.  Middelburg KJ, Heineman MJ, Haadsma ML, Bos AF, Kok JH, Hadders-Algra M. Neurological condition of infants born following preimplantation genetic screening. Pediatr Res 2010, e-pub ahead of print..
  7. Schendelaar P, Middelburg KJ, Bos AF, Heineman MJ, Jongbloed-Pereboom M, Hadders-Algra M. The Groningen ART-cohort study: the effects of ovarian hyperstimulation and the IVF laboratory procedures on neurological condition at 2 years. Hum Reprod, in press.